1.
Bioorg Med Chem Lett
; 21(1): 288-93, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21106375
RESUMO
In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.
